References

363

(cf. Fig. 23.1). Instead of people having a biannual or even just annual blood test,

hourly fluctuations could then be monitored, leading to an explosion of actimetry

(activimetry) as a way of characterizing physiological state.

References

Awdeh ZL, Alper CA (2005) Mendelian inheritance of polygenic diseases: a hypothetical basis for

increasing incidence. Med Hypotheses 64:495–498

Awdeh ZL, Yunis EJ, Audeh MJ, Fici D, Pugliese A, Larsen CE, Alper CA (2006) A genetic

explanation for the rising incidence of type 1 diabetes, a polygenic disease. J Autoimmun 27:174–

181

Chumakov S et al (2005) The theoretical basis of universal identification systems for bacteria and

viruses. J Biol Phys Chem 5:121–128

Cross D (2015) An unhealthy obsession with fluoride. Nanotechnol Percept 11:169–185

Eckman MH, Greenberg SM, Rosand J (2009) Should we test for CYP2C19 before initiating

anticoagulant therapy in patients with atrial fibrillation? J Gen Intern Med 24:543–549

Foster KR, Shaulsky G, Strassman JE, Queller DC, Thompson CRL (2004) Pleiotropy is a mecha-

nism to stabilize cooperation. Nature 431:693–696

Hermsen R, Deris JB, Hwa T (2012) On the rapidity of antibiotic resistance evolution facilitated

by a concentration gradient. Proc Natl Acad Sci USA 109:10775–10780

Jakobsson M et al (2008) Genotype, haplotype and copy-number variation in worldwide human

populations. Nature 451:998–1003

Kepler TB, Perelson AS (1998) Drug concentration heterogeneity facilitates the evolution of drug

resistance. Proc Natl Acad Sci USA 95:11514–11519

Kim H, Lee Y-G, Kim N (2013) Bioinformatics interpretation of exome sequencing: blood cancer.

Genomics Inform 11:24–33

Lin J, Wu G, Zhao Z, Huang Y, Chen J, Fu C, Ye J, Liu X (2018) Bioinformatics analysis to identify

key genes and pathways influencing synovial inflammation in osteoarthritis. Molec Med Rep

18:5594–5602

Manolio TA, Brooks LD, Collins FS (2008) A HapMap harvest of insights into the genetics of

common disease. J Clin Investig 118:1590–1605

Mossink B et al (2012) Human neuronal networks on micro-electrode arrays are a highly robust tool

to study disease-specific genotype-phenotype correlations in vitro. Stem Cell Rep 16:2182–2196

Murry CE, Keller G (2008) Differentiation of embryonic stem cells to clinically relevant populations:

lessons from embryonic development. Cell 132:661–680

Myers RH (2006) Considerations for genomewide association studies in Parkinson disease. Am J

Human Genet 78:1081–1082

Oh JH, Craft JM, Townsend R, Deasy JO, Bradley JD, Naqa IE (2011) A bioinformatics approach

for biomarker identification in radiation-induced lung inflammation from limited proteomics data.

J Proteome Res 10:1406–1415

Paynter NP et al (2009) Cardiovascular disease risk prediction with and without knowledge of

genetic variation at chromosome 9p21.3. Ann Internal Med 150:65–72

Pritchard JK, Cox NJ (2002) The allelic architecture of human disease genes: common disease—

common variantellipsis. . . or not? Human Molec Genet 11:2417–2423

Ramsden JJ (2001) Computational aspects of consciousness. Psyche Problem Perspect 1:93–100

Ramsden JJ (2021) Reform of the NHS. J Biol Phys Chem 21:107–118

Risch N, Merikangas K (1996) The future of genetic studies of complex human diseases. Science

273:1516–1517

Sander JD, Joung JK (2014) CRISPR-Cas systems for editing, regulating and targeting genomes.

Nat Biotechnol 32:347–355